Matthew B. Harms, MD
On the web
Overview
Matthew B. Harms, MD, is Professor of Neurology and a neurogeneticist at Columbia University Irving Medical Center in New York City. He earned his undergraduate degree in Biology from Harvard University and his medical degree from the University of California, San Francisco (UCSF), where he also completed his neurology residency and served as chief resident. He subsequently completed fellowships in clinical neurophysiology and neurogenetics at Washington University in St. Louis, where he joined the faculty before moving to Columbia University in 2015.
Dr. Harms is Associate Director of the Eleanor and Lou Gehrig ALS Center and Director of the Program in Neurogenetics at Columbia. His research focuses on identifying the genetic causes of amyotrophic lateral sclerosis (ALS) and related motor neuron disorders, understanding genotype–phenotype relationships, interpreting rare genetic variants, and studying individuals who carry ALS-associated genetic variants before symptom onset.
He serves in leadership roles within the Clinical Genome Resource (ClinGen), including as Co-Chair of the Neurological Disorders Clinical Domain Working Group and Chair of the ALS and Related Motor Neuron Disease Gene and Variant Curation Expert Panels. He also serves on the scientific advisory board of the Network for Excellence in ALS Research (NEALS). He is also the Editor-in-Chief of Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.
Areas of Expertise / Conditions Treated
- ALS (Amyotrophic Lateral Sclerosis)
- Becker Muscular Dystrophy (BMD)
- Clinical Research
- Congenital Muscular Dystrophy (CMD)
- Duchenne Muscular Dystrophy (DMD)
- Facioscapulohumeral Muscular Dystrophy (FSHD)
- Limb-Girdle Muscular Dystrophy (LGMD)
- Lou Gehrig's Disease
- Metabolic Myopathy
- Mitochondrial Diseases
- Muscular Dystrophy
- Myofibrillar Myopathy
- Myopathy
- Neurogenetics
- Peripheral Neuropathy
Academic Appointments
- Professor of Neurology at the CUMC
Hospital Affiliations
- NewYork-Presbyterian / Columbia University Irving Medical Center
Gender
- Male
Schedule an Appointment
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Phone Appointments
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Location(s)
Insurance Accepted
For billing questions, please call (212) 342-4432.
Aetna
- Aetna Signature Administrators
- EPO
- HMO
- Medicare Managed Care
- NY Signature
- POS
- PPO
- Student Health
Affinity Health Plan
- Essential Plan
- Medicaid Managed Care
Amida Care
- Special Needs
Cigna
- EPO
- Great West (National)
- HMO
- POS
- PPO
ElderServe
- Special Needs
Emblem/GHI
- Medicare Managed Care
- PPO
Emblem/HIP
- ConnectiCare
- EPO
- Essential Plan
- HMO
- Medicaid Managed Care
- Medicare Managed Care
- POS
- PPO
- Select Care (Exchange)
- Vytra
Empire Blue Cross/Blue Shield
- EPO
- HMO
- Medicare Managed Care
- PPO
Empire Blue Cross Blue Shield HealthPlus
- Child/Family Health Plus
- Essential Plan
- Individual Network (Exchange)
- Medicaid Managed Care
Fidelis Care
- Child/Family Health Plus
- Essential Plan
- Medicaid Managed Care
- Medicare Managed Care
Healthfirst
- Child/Family Health Plus
- Leaf (Exchange)
- Medicaid Managed Care
- Medicare Managed Care
Healthspring (Cigna Medicare)
- Medicare Managed Care
Local 1199
- Local 1199
MagnaCare (National)
- MagnaCare
Medicare
- Traditional Medicare
Multiplan
- Multiplan
MVP Health Care
- Child/Family Health Plus
- Essential Plan
- HMO
- Medicaid Managed Care
UnitedHealthcare
- Empire Plan
- HMO
- Medicaid (Community Plan)
- Medicare Managed Care
- Oxford Freedom
- Oxford HMO
- Oxford Liberty
- POS
- PPO
VNSNY CHOICE
- Medicare Managed Care
- SelectHealth
- Special Needs
WellCare
- Medicaid Managed Care
- Medicare Managed Care
World Trade Center Health Plan
- World Trade Center Health Plan
Credentials & Experience
Education & Training
- MD, University of California San Francisco School of Medicine
- Internship: University of California San Francisco Medical Center
- Residency: University of California San Francisco Medical Center
- Fellowship: 2008 Barnes Jewish Hospital/Washington University
- Fellowship: 2009 Barnes Jewish Hospital
Board Certifications
- Clinical Neurophysiology
- Neurology
- Neuromuscular Medicine
Research
Selected Publications
O'Rourke JG, Bogdanik L, Yanez A, Lall D, Wolf AJ, Muhammad AKMG, Ho R, Carmona S, Vit JP, Zarrow J, Kim K, Bell S, Harms MB, Miller TM, Dangler C, Underhill DM, Goodridge HS, Lutz CM, Baloh RH. C9ORF72 is required for proper machrophage and microglial function in mice. Science. 2016, Mar 18;351(6279):1324-9.
O'Rourke JG, Bogdanik L, Muhammad AK, Gendron TF, Kim KJ, Austin A, Cady J, Liu EY, Zarrow J, Grant S, Ho R, Bell S, Carmona S, Simpkinson M, Lall D, Wu K, Daughrity L, Dickson DW, Harms MB, Petrucelli L, Lee EB, Lutz CM, Baloh RH. C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD. Neuron. 2015, Dec 2;88(5):892-901.
Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, .. Harms MB, et al, Goldstein DB. Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science, 2015, Mar 27,347(6229):1436-41.
*Weihl CC, Baloh RH, Lee Y, Chou TF, Pittman SK, Lopate G, Allred P, Jockel-Balsarotti J, Pestronk A, Harms MB. Targeted sequencing and identification of genetic variants in sporadic inclusion body myositis. Neuromuscul Disord. 2015, Apr;25(4):289-96.
*Cady J, Koval ED, Benitez BA, Zaidman C, Jockel-Balsarotti J, Allred P, Baloh RH, Ravits J, Simpson E, Appel SH, Pestronk A, Goate AM, Miller TM, Cruchaga C, Harms MB. TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis. JAMA Neurol. 2014, Apr;71(4):449-53.
Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, Pittman A, Orrell RW, Malaspina A, Sidle KC, Fratta P, Harms MB, Baloh RH, Pestronk A, Weihl CC, Rogaeva E, Zinman L, Drory VE, Borghero G, Mora G, Calvo A, Rothstein JD; ITALSGEN Consortium, Drepper C, Sendtner M, Singleton AB, Taylor JP, Cookson MR, Restagno G, Sabatelli M, Bowser R, Chiò A, Traynor BJ. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nat Neurosci. 2014, May;17(5):664-6.
Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD, Bennett CF, Cleveland DW, Ravits J. Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci U S A. 2013, Nov 19;110(47):E4530-9.
δHarms M, Benitez BA, Cairns N, Cooper B, Cooper P, Mayo K, Carrell D, Faber K, Williamson J, Bird T, Diaz-Arrastia R, Foroud TM, Boeve BF, Graff-Radford NR, Mayeux R, Chakraverty S, Goate AM, δCruchaga C; NIA-LOAD/NCRAD Family Study Consortium. C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease. JAMA Neurol. 2013, Jun;70(6):736-41. δAuthors contributed equally.
Harms MB, Neumann D, Benitez BA, Cooper B, Carrell D, Racette BA, Perlmutter JS, Goate A, Cruchaga C. Parkinson disease is not associated with C9ORF72 repeat expansions. Neurobiol Aging. 2013, May;34(5):1519.e1-2. doi:10.1016
Harms MB, Ori-McKenney KM, Scoto M, Tuck EP, Bell S, Ma D, Masi S, Allred P, Al-Lozi M, Reilly MM, Miller LJ, Jani-Acsadi A, Pestronk A, Shy ME, Muntoni F, Vallee RB, Baloh RH. Mutations in the tail domain of DYNC1H1 cause dominant spinal muscular atrophy. Neurology. 2012, May 29;78(22):1714-20.
Hakeda-Suzuki S, Ng J, Tzu J, Dietzl G, Sun Y, Harms M, Nardine T, Luo L, Dickson BJ. Rac function and regulation during Drosophila development. Nature. 2002, Mar 28;416(6879):438-42.
Ng J, Nardine T, Harms M, Tzu J, Goldstein A, Sun Y, Dietzl G, Dickson BJ, Luo L. Rac GTPases control axon growth, guidance and branching. Nature. 2002, Mar 28;416(6879):442-7.
For a complete list of publications, please visit PubMed.gov